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Time-course transcriptome analysis of medullary thymic epithelial cells in the early phase of thymic involution.

This group reports declines in cell cycle-related genes during thymic involution in mice--as early as 2-6 weeks after birth. They also note an increase in the expression of inflammatory factors that appear much like the SASP. It's not clear to me what age 2-6 weeks in mice translates to in humans. I'm confident some individuals on this distribution list will know better than me.
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Expression of p16INK 4a is a biomarker of chondrocyte aging but does not cause osteoarthritis.

This group reports that p16ink4a expression and SASP can be decoupled; inactivation of p16ink4a does not mitigate SASP expression during aging or osteoarthritis. This suggests to me: perhaps p16ink4a, as a cyclin-dependent kinase inhibitor, is a controller of the cell cycle and not directly related to senescence. Maybe SASP and cell cycle arrest simply often happen at the same time in the same place, but aren't necessarily tightly linked? Maybe some readers already new this...
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Reduction of Proliferating Olfactory Cells and Low Expression of Extracellular Matrix Genes Are Hallmarks of the Aged Olfactory Mucosa.

I thought this report was remarkable because they report that the number of olfactory progenitors did not decline with age in mice, but the number of olfactory receptor neurons and proliferating cells did. This made me wonder: what is keeping the progenitors from maintaining/restoring the declining number of mature olfactory receptor neurons? These researchers suggest SASP, or some of its components, may play a role.
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Aging promotes neoplastic disease through effects on the tissue microenvironment.

From the abstract, these results appear to be support the theory that senescent cells and SASP facilitate cancer development. Here, these researchers report that transplanted pre-neoplastic liver cells caused no lesions in young animals, but did cause nodules or tumors in 17/18 older animals. They further note that SAbeta-gal expression was common in older animals, but rare in young animals; IL-6 and its mRNA were also increased in older animals.
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Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

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An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

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