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White matter hyperintensities on MRI in dementia with Lewy bodies, Parkinson’s disease with dementia, and Alzheimer’s disease.

This group reports on some assessments of brain changes in different age-related brain diseases. They conclude that medial temporal lobe atrophy correlated with white matter hyperintensity severity. In their analysis, they also apparently made a distinction between AD-related pathology and atherosclerotic changes in the brain (that these seem to be distinctly different pathogenic processes).
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Parkinson’s Disease Skin Fibroblasts Display Signature Alterations in Growth, Redox Homeostasis, Mitochondrial Function, and Autophagy.

This group reports that skin fibroblasts taken from people with late-onset sporadic Parkinson's differ remarkably from healthy controls. Some differences include a "striking" increase in baseline macroautophagy, compromised mitochondrial structure, and sensitivity to UVA irradiation. Could there be some link between these differences in skin fibroblasts and the pathogenesis of Parkinson's? Could these differences be used as clinical endpoints in Parkinson's trials?
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α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson’s disease.

I'm skeptical that an in vitro model of this situation would accurately represent what happens in humans with Parkinson's disease, but I'll leave it up to readers to decide. Here, these researchers report that alpha-synuclein appears to disrupt trafficking of lysosomal hydrolases, which could be the cause of accumulated alpha-synuclein and ferritin in the eyes of people with Parkinson's.
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Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

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Free longevity biomarker report

Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

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Free diabetes report

An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

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