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Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice.


Maximus Peto’s Commentary

Although the experiments were done in mice, this report makes me wonder whether administration of MSCs may help alleviate or reverse age-related neurodegenerative conditions.


Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice.
Front Pharmacol. 2019 Apr 17;10:355.
Olena Lykhmus, Lyudmyla Koval, Larysa Voytenko, Kateryna Uspenska, Serhiy Komisarenko, Olena Deryabina, Nadia Shuvalova, Vitalii Kordium, Alina Ustymenko, Vitalii Kyryk, Maryna Skok
DOI: 10.3389/fphar.2019.00355
PubMed publication date (edat): 5/7/2019

Abstract

…In the present study, we aimed to investigate whether pathogenic effect of LPS on the brain and behavior of mice can be prevented or treated by injection of MSCs or MSC-produced soluble factors. Fluorescently-labeled MSCs, injected intravenously, were found in the brain blood vessels of LPS-treated mice. Mice co-injected with LPS and MSCs did not demonstrate episodic memory impairment, Aβ (1-42) accumulation, and nAChR decrease in the brain and brain mitochondria. Their mitochondria released less cytochrome c under the effect of Ca2+ compared to mitochondria of LPS-only-treated mice. Moreover, MSCs could reverse the pathogenic symptoms developed 3 weeks after LPS injection. Cultured MSCs produced IL-6 in response to LPS and MSCs effect in vivo was accompanied by additional stimulation of both micro- and macroglia. Xenogeneic (human) MSCs were almost as efficient as allogeneic (mouse) ones and regular injections of human MSC-conditioned medium also produced positive effect. These data allow suggesting MSCs as a potential therapeutic tool to cure neuroinflammation-related cognitive pathology.

PMID: 31057400
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479176/

Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

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