Maximus Peto’s Commentary
This group reports on what seem to be remarkable positive effects of bone marrow transplant in mice, with a significant extension of maximal and remaining lifespan when transplanted to mice at the age when half of the population had already died. These results may suggest the importance of stem cells in mammalian lifespan.
Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice.
Front Genet. 2019 Apr 12;10:310.
Kovina MV, Karnaukhov AV, Krasheninnikov ME, Kovin AL, Gazheev ST, Sergievich LA, Karnaukhova EV, Bogdanenko EV, Balyasin MV, Khodarovich YM, Dyuzheva TG, Lyundup AV
PubMed publication date (edat): 4/30/2019
The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated animal was performed at the time when half of the population had already died. As a result, the maximum lifespan (MLS) increased by 28 ± 5%, and the survival time from the beginning of the experiment increased 2.8 ± 0.3-fold. The chimerism of the BM 6 months after the transplantation was 28%.
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473025/