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Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging.


Maximus Peto’s Commentary

This group reports that proinflammatory cytokines can cause senescence in young adult thymic epithelial cells, suggesting a possible relationship between senescent cells, SASP, and thymic involution.


Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging.
Aging Cell. 2019 Aug;18(4):e12952.
Yue S, Zheng X, Zheng Y
DOI: 10.1111/acel.12952
PubMed publication date (edat): 4/11/2019

Abstract

Cellular architectural proteins often participate in organ development and maintenance. Although functional decay of some of these proteins during aging is known, the cell-type-specific developmental role and the cause and consequence of their subsequent decay remain to be established especially in mammals. By studying lamins, the nuclear structural proteins, we demonstrate that lamin-B1 functions specifically in the thymic epithelial cells (TECs) for proper thymus organogenesis. An up-regulation of proinflammatory cytokines in the intra-thymic myeloid immune cells during aging accompanies a gradual reduction of lamin-B1 in adult TECs. We show that these cytokines can cause senescence and lamin-B1 reduction of the young adult TECs. Lamin-B1 supports the expression of TEC genes that can help maintain the adult TEC subtypes we identified by single-cell RNA-sequencing, thymic architecture, and function. Thus, structural proteins involved in organ building and maintenance can undergo inflammation-driven decay which can in turn contribute to age-associated organ degeneration.

PMID: 30968547
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612680/

Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

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