Maximus Peto’s Commentary
This group reports that proinflammatory cytokines can cause senescence in young adult thymic epithelial cells, suggesting a possible relationship between senescent cells, SASP, and thymic involution.
Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging.
Aging Cell. 2019 Aug;18(4):e12952.
Yue S, Zheng X, Zheng Y
PubMed publication date (edat): 4/11/2019
Cellular architectural proteins often participate in organ development and maintenance. Although functional decay of some of these proteins during aging is known, the cell-type-specific developmental role and the cause and consequence of their subsequent decay remain to be established especially in mammals. By studying lamins, the nuclear structural proteins, we demonstrate that lamin-B1 functions specifically in the thymic epithelial cells (TECs) for proper thymus organogenesis. An up-regulation of proinflammatory cytokines in the intra-thymic myeloid immune cells during aging accompanies a gradual reduction of lamin-B1 in adult TECs. We show that these cytokines can cause senescence and lamin-B1 reduction of the young adult TECs. Lamin-B1 supports the expression of TEC genes that can help maintain the adult TEC subtypes we identified by single-cell RNA-sequencing, thymic architecture, and function. Thus, structural proteins involved in organ building and maintenance can undergo inflammation-driven decay which can in turn contribute to age-associated organ degeneration.
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612680/