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Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.


Maximus Peto’s Commentary

These look like some interesting positive effects of the senolytic navitoclax on recovery from myocardial infarction.


Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction.
Aging Cell. 2019 Jun;18(3):e12945.
Walaszczyk A, Dookun E, Redgrave R, Tual-Chalot S, Victorelli S, Spyridopoulos I, Owens A, Arthur HM, Passos JF, Richardson GD
DOI: 10.1111/acel.12945
PubMed publication date (edat): 3/29/2019

Abstract

Cardiovascular disease is the leading cause of death in individuals over 60 years old. Aging is associated with an increased prevalence of coronary artery disease and a poorer prognosis following acute myocardial infarction (MI). With age, senescent cells accumulate in tissues, including the heart, and contribute to age-related pathologies. However, the role of senescence in recovery following MI has not been investigated. In this study, we demonstrate that treatment of aged mice with the senolytic drug, navitoclax, eliminates senescent cardiomyocytes and attenuates profibrotic protein expression in aged mice. Importantly, clearance of senescent cells improved myocardial remodelling and diastolic function as well as overall survival following MI. These data provide proof-of-concept evidence that senescent cells are major contributors to impaired function and increased mortality following MI and that senolytics are a potential new therapeutic avenue for MI.

PMID: 30920115
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516151/

Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

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