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NAD+ supplementation rejuvenates aged gut adult stem cells.


Maximus Peto’s Commentary

This group reported that nicotinamide riboside could “rejuvenate” intestinal stem cells from aged mice and “reverses an impaired ability to repair gut damage”. Interestingly, it appears that mTORC1 inhibition (via rapamycin administration) could prevent this effect, suggesting that NAD+ restoration may work through increased mTORC1 activity to restore some tissues.


NAD+ supplementation rejuvenates aged gut adult stem cells.
Aging Cell. 2019 Jun;18(3):e12935.
Igarashi M, Miura M, Williams E, Jaksch F, Kadowaki T, Yamauchi T, Guarente L
DOI: 10.1111/acel.12935
PubMed publication date (edat): 3/28/2019

Abstract

The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, as does ISC function assessed ex vivo. Levels of SIRT1 and activity of mTORC1 also decline with aging. The treatment with the NAD(+) precursor nicotinamide riboside (NR) rejuvenates ISCs from aged mice and reverses an impaired ability to repair gut damage. The effect of NR is blocked by the mTORC1 inhibitor rapamycin or the SIRT1 inhibitor EX527. These findings demonstrate that small molecules affecting the NAD/SIRT1/mTORC1 axis may guide a translational path for maintenance of the intestine during aging.

PMID: 30917412
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516145/

Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

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