skip to Main Content

Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence.


Maximus Peto’s Commentary

This group reported some associations between AMPK activation and what appeared to be prevention or reversal of cellular senescence. I found the exercise part of this study particularly interesting: treadmill exercise in mice reduced p16 and p21 expression in older sedentary mice. Could this be representative of a reversal of senescence? If so, how might it be recapitulated in other tissue types? In response to a similar study I reported on, if I recall correctly, Aubrey mentioned that exercise reducing/reversing senescence was not surprising because exercise would help nutrient uptake. If that’s true, I wonder whether other tissues (e.g. skin) might experience increased senescence because of relatively poor nutrient uptake (perhaps after adolescence when growth factors that facilitate nutrient uptake decline). For example, I have yet to figure out how to flex my skin (to improve nutrient uptake)! Aubrey and others, what do you think of this concept?


Exercise-induced AMPK activation is involved in delay of skeletal muscle senescence.
Biochem Biophys Res Commun. 2019 May 7;512(3):604-610.
Yoon KJ, Zhang D, Kim SJ, Lee MC, Moon HY
DOI: 10.1016/j.bbrc.2019.03.086
PubMed publication date (edat): 3/27/2019

Abstract

Accumulation of senescent cells leads to aging related phenotypes in various organs. Sarcopenia is a frequently observed aging-related disease, which is associated with the loss of muscle mass and functional disability. Physical activity represents the most critical treatment method for preventing decreased muscle size, mass and strength. However, the underlying mechanism as to how physical activity provides this beneficial effect on muscle function has not yet been fully understood. In particular, one unresolved question about aging is how the boost in catabolism induced by aerobic exercise affects skeletal muscle atrophy and other senescence phenotypes. Here we show that pre-activation of AMPK with the AMPK activator, AICAR can mitigate the diminished cellular viability of skeletal muscle cells induced by doxorubicin, which accelerates senescence through free radical production. Pre-incubation for 3 h with AICAR decreased doxorubicin-induced phosphorylation of AMPK in a differentiated skeletal muscle cell line. Accordingly, cellular viability of skeletal muscle cells was recovered in the cells pre-treated with AICAR then administered doxorubicin as compared to that of doxorubicin-only treatment. In accordance with the results of cellular experiments, we verified that 4 weeks of treadmill exercise decreased the senescence marker, p16 and p21 in 19-month-old mice compared to sedentary mice. In this study, we provide new evidence that prior activation of AMPK can reduce doxorubicin induced cell senescence phenotypes. The evidence in this paper suggest that aerobic exercise-activated catabolism in the skeletal muscle may prevent cellular senescence, partially through the cell cycle regulation.

PMID: 30910357
Free Full-Text:

Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

Coming soon. We’ll send you the report as soon as it’s published.

*We do not share your email address with anyone.

Free longevity biomarker report

Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

Coming soon. We’ll send you the report as soon as it’s published.

*We do not share your email address with anyone.

Free diabetes report

An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

Coming soon. We’ll send you the report as soon as it’s published.

*We do not share your email address with anyone.

Back To Top