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Detection of Parkinson’s Disease through the Peptoid Recognizing α-Synuclein in Serum.


Maximus Peto’s Commentary

These look like some interesting results of research using a “peptoid” with high affinity and specificity to alpha-synuclein in the serum; it could apparently (I presume) distinguish between Parkinson’s disease and normal controls.


Detection of Parkinson’s Disease through the Peptoid Recognizing α-Synuclein in Serum.
ACS Chem Neurosci. 2019 Mar 20;10(3):1204-1208.
Gao H, Zhao Z, He Z, Wang H, Liu M, Hu Z, Cheng O, Yang Y, Zhu L
DOI: 10.1021/acschemneuro.8b00540
PubMed publication date (edat): 1/27/2019

Abstract

Parkinson’s disease (PD) is a severe neurodegenerative disease and there is great need for developing a biochemical detection method to precisely diagnose it. Alpha-synuclein (α-syn) participates in the main pathology of PD and serves as an important biomarker of PD. Here, we identified peptoid ASBP-7 that had high affinity and specificity to α-syn by screening a peptoid library using the high-throughput surface plasmon resonance imaging method. We confirmed that ASBP-7 could significantly distinguish PD sera from the normal ones through identifying α-syn in the serum. We also demonstrated the high sensitivity of this system in detecting PD serum. This work provides a method for the blood-based, label-free, high-throughput analysis of PD serum, and holds great potential for the early diagnosis and dynamic monitoring of PD.

PMID: 30682886
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Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

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