Maximus Peto’s Commentary
These look like some interesting results of research using a “peptoid” with high affinity and specificity to alpha-synuclein in the serum; it could apparently (I presume) distinguish between Parkinson’s disease and normal controls.
Detection of Parkinson’s Disease through the Peptoid Recognizing α-Synuclein in Serum.
ACS Chem Neurosci. 2019 Mar 20;10(3):1204-1208.
Gao H, Zhao Z, He Z, Wang H, Liu M, Hu Z, Cheng O, Yang Y, Zhu L
PubMed publication date (edat): 1/27/2019
Parkinson’s disease (PD) is a severe neurodegenerative disease and there is great need for developing a biochemical detection method to precisely diagnose it. Alpha-synuclein (α-syn) participates in the main pathology of PD and serves as an important biomarker of PD. Here, we identified peptoid ASBP-7 that had high affinity and specificity to α-syn by screening a peptoid library using the high-throughput surface plasmon resonance imaging method. We confirmed that ASBP-7 could significantly distinguish PD sera from the normal ones through identifying α-syn in the serum. We also demonstrated the high sensitivity of this system in detecting PD serum. This work provides a method for the blood-based, label-free, high-throughput analysis of PD serum, and holds great potential for the early diagnosis and dynamic monitoring of PD.