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Distinct effect of age, sex, and CMV seropositivity on dendritic cells and monocytes in human blood.


Maximus Peto’s Commentary

This group reported that the number of plasmacytoid dendritic cells appeared to decrease with age in CMV-positive individuals, while myeloid dendritic cells and monocytes were unchanged with CMV. On an unrelated note, it appears to be an interesting coincidence that the age range of the study subjects were almost identical to those of the previous study about brain changes correlating with chronological age. Could they have used the same cohort?


Distinct effect of age, sex, and CMV seropositivity on dendritic cells and monocytes in human blood.
Immunol Cell Biol. 2018 Jan;96(1):114-120.
Puissant-Lubrano B, Apoil PA, Guedj K, Congy-Jolivet N, Roubinet F, Guyonnet S, Sourdet S, Nourhashemi F, Blancher A
DOI: 10.1111/imcb.1004
PubMed publication date (edat): 1/24/2018

Abstract

We analyzed the impact of age, sex, and CMV on blood monocyte and dendritic cell (DC) subpopulations in 256 healthy individuals aged from 19 to 96 years. Flow cytometry was performed on whole blood within the 4 h following blood drawing. Myeloid (mDC) and plasmacytoid DC (pDC), classical, intermediate, and nonclassical monocytes were enumerated by means of TruCount tubes (BD Biosciences). We provided reference values for mDC, pDC and the three monocyte subpopulations. The numbers of classical, intermediate, and nonclassical monocytes slightly increased with age while the numbers of mDC and pDC did not vary significantly. The level of expression of CD64 and CD163 on monocytes significantly increased with age while HLA-DR expression did not vary significantly. More precisely, CD163 expression level on intermediate monocyte slightly increased with age in women only (Spearman P = 0.019) while CD64 expression increased on monocytes in CMV-positive individuals only. We observed that sex had almost no impact on the numbers of monocytes and DC and on their expression level of CD64 and HLA-DR. We observed a significant decrease in the numbers of pDC with age in CMV-positive individuals, but not in CMV negative individuals. This suggests that the lifelong subclinical infection by CMV could influence the number of circulating DC of lymphoid origin. In contrast, CMV serostatus had no significant impact on absolute numbers of mDC and monocytes.

PMID: 29359459
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Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

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