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Recent advances in CMV tropism, latency, and diagnosis during aging.


Maximus Peto’s Commentary

This report looks like conference notes from a conference about CMV. Perhaps there are interesting new ideas about CMV to consider in it.


Recent advances in CMV tropism, latency, and diagnosis during aging.
Geroscience. 2017 Jun;39(3):251-259.
Leng SX, Kamil J, Purdy JG, Lemmermann NA, Reddehase MJ, Goodrum FD
DOI: 10.1007/s11357-017-9985-7
PubMed publication date (edat): 7/7/2017

Abstract

Human cytomegalovirus (CMV) is one of the largest viruses known to cause human diseases. Chronic CMV infection, as defined by anti-CMV IgG serology, increases with age and is highly prevalent in older adults. It has complex biology with significant immunologic and health consequences. This article aims to summarize research findings presented at the 6th International Workshop on CMV and Immunosenescence that relate to advances in the areas of CMV tropism, latency, CMV manipulation of cell metabolism, and T cell memory inflation, as well as novel diagnostic evaluation and translational research of chronic CMV infection in older adults. Information summarized here represents the current state of knowledge in these important fields. Investigators have also identified a number of areas that deserve further and more in-depth investigation, including building more precise parallels between mouse CMV (mCMV) and human CMV (HCMV) research. It is hoped that this article will also stimulate engaging discussion on strategies and direction to advance the science to the next level.

PMID: 28681110
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505884/

Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

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