Maximus Peto’s Commentary
These researchers assessed different subsets of T-cells, to evaluate which subsets change with age, and how they change with age, with particular reference to their secretion profile of the cytokines interferon-gamma and tumor necrosis factor-alpha.
Vδ2+ and α/ß T cells show divergent trajectories during human aging.
Oncotarget. 2016 Jul 19;7(29):44906-44918.
Tan CT1, Wistuba-Hamprecht K2,3, Xu W1,4, Nyunt MS5, Vasudev A1, Lee BT1, Pawelec G2, Puan KJ1, Rotzschke O1, Ng TP5, Larbi A1,4,6.
PubMed publication date (edat): 7/8/2016
Chronological aging and a variety of stressors are driving forces towards immunosenescence. While much attention was paid to the main T cell component, α/β T cells, few studies concentrate on the impact of age on γ/δ T cells’ characteristics. The latter are important players of adaptive immunity but also have features associated with innate immunity. Vδ2+ are the main component of γ/δ while Vδ1+ T cells expand upon Cytomegalovirus (CMV) infection and with age. The Vδ2+ T cells are not influenced by persistent infections but do contribute to immunosurveillance against bacterial pathogens. Here, we focus on Vδ2+ T cells and report that their composition and functionality is not altered in older adults. We have performed a side-by-side comparison of α/β and Vδ2 cells by using two robust markers of T cell replicative history and cell differentiation (CD28 and CD27), and cytokine secretion (IFN-γ and TNF-α). Significant differences in Vδ2 versus α/β homeostasis, as well as phenotypic and functional changes emerged. However, the data strongly suggest a sustained functionality of the Vδ2 population with age, independently of the challenge. This suggests differential trajectories towards immunosenescence in α/β and Vδ2+ T cells, most likely explained by their intrinsic functions.
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216693/