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T-cell senescence contributes to abnormal glucose homeostasis in humans and mice.

There have been some reports suggesting that aging is associated with impaired insulin sensitivity, and there are many studies reporting an age-associated increase in some inflammatory factors. This group reports that it may be senescent CD8+ T cells that contribute to both of these phenomena. Among other observations, they found that humans with diabetes or prediabetes had higher levels of senescent T cells, which in turn had higher expression levels of cytokines and cytotoxic molecules. Mouse models of aging and diet-induced obesity also had some of these characteristics.
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The Reparative Effects of Human Adipose-Derived Mesenchymal Stem Cells in the Chemotherapy-Damaged Thymus.

This looks like a remarkable report of human adipose-derived mesenchymal stem cells (hADMSCs) rejuvenating the mouse thymus after chemotherapy. This group reported that hADMSC treatment resulted in homing of the MSCs to the thymus and apparently improved thymic recovery rate after chemotherapy, though they didn't comment in the abstract on whether this caused any changes in T cell production and mobilization.
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Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

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Free longevity biomarker report

Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

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Free diabetes report

An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

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