skip to Main Content

Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells.

This seems potentially important to know about, for example, in the case that these founder cells are damaged or eliminated during aging. This group reports on their characterization of what they call "pluripotent founder cells", which seem to be foundational in a population of pluripotent stem cells. These cells "are marked by N-cadherin expression...reside exclusively at the colony boundary of primate pluripotent stem cells..." and "emerge prior to commitment events or phenotypes associated with pluripotent reprogramming".
Read More

NAD+ supplementation rejuvenates aged gut adult stem cells.

This group reported that nicotinamide riboside could "rejuvenate" intestinal stem cells from aged mice and "reverses an impaired ability to repair gut damage". Interestingly, it appears that mTORC1 inhibition (via rapamycin administration) could prevent this effect, suggesting that NAD+ restoration may work through increased mTORC1 activity to restore some tissues.
Read More

Microfluidic reprogramming to pluripotency of human somatic cells.

This may not be of direct interest to us, but the apparent technological and economic implications of this report seem noteworthy and relevant enough for us to know about. This group reports using microfluidics systems to manufacture human induced pluripotent stem cells ("hiPSCs") in xeno-free, defined conditions, using only 20 uL of growth medium per day, resulting in an "~100-fold reduction in costs of raw materials compared to those for standard multiwell culture conditions". This seems like a remarkable advancement.
Read More

Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

Coming soon. We’ll send you the report as soon as it’s published.

*We do not share your email address with anyone.

Free longevity biomarker report

Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

Coming soon. We’ll send you the report as soon as it’s published.

*We do not share your email address with anyone.

Free diabetes report

An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

Coming soon. We’ll send you the report as soon as it’s published.

*We do not share your email address with anyone.

Back To Top