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Topical applications of an emollient reduce circulating pro-inflammatory cytokine levels in chronically aged humans: a pilot clinical study.

I found this study interesting: topical application of an emollient to the skin (i.e. applying lotion) "normalized" several * systemic* inflammatory factors such as IL-6 in older humans. This makes me wonder: how much of the increase in circulating inflammatory factors during aging could be caused by dysfunctional, damaged, or senescent skin? I wonder how long this reduction of inflammation persisted after the application of emollient.
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Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes.

There have been some reports that nicotinamide can affect human mortality from skin cancer (e.g. see PMIDs 22297641 and 28468736), and I presume NAD+ replenishment is at least of some interest to Methuselah and SRF. Here, this group reports that nicotinamide significantly affects differentiation and proliferation of different types of skin cells in cell culture, and these effects can be influenced by impairing nicotinamide's conversion to NAD+, suggesting that NAD+ might be involved in this association between skin cancer and nicotinamide.
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PhotoAgeClock: deep learning algorithms for development of non-invasive visual biomarkers of aging.

This group reports on a predictor of chronological age using anonymized images of eye corners. They found that for people between 20 and 80 "in a specific population" (I wonder which), "the model was able to achieve a mean absolute error of 2.3 years and 95% Pearson and Spearman correlation". This doesn't tell us much about stable, accumulating, age-related damage or how to fix it, but it might be a useful method of assessing interventions intended to rejuvenate aged humans, the skin in particular.
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Free report on high blood pressure

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