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Lipofuscin-dependent stimulation of microglial cells.

With this study being in cell culture, I have doubts about its relevance to the development of human age-related macular degeneration. But his group reported that microglia "quickly and completely" phagocytosed lipofuscin, and this was associated with "highly elevated levels of pro-inflammatory cytokines...in the cell culture supernatants". They go on to suggest perhaps this interaction between microglia and lipofuscin might be a cause of inflammation and angiogenesis in AMD.
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MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells.

From this report, it appears that miR-29 may have an important role in regulating autophagy, at least in RPE cells in cell culture. This group reported that miR-29 overexpression increased autophagic activity, but from the abstract, they apparently didn't observe a reduction in lipofuscin or drusen--something they said they tried to find. But they did note that miR-29 overexpression "enhances autophagy which aids in the removal of protein aggregates".
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Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

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Free longevity biomarker report

Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

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Free diabetes report

An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

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