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Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria.

I have reported previously on studies about glucose metabolism in Alzheimer's disease. This research group reported on their investigation of using [18F]FDG-PET to diagnose dementia with Lewy bodies and to discriminate it from Alzheimer's and Parkinson's diseases. The results look interesting; based on where the glucose hypometabolism is observed in the brain, "hypometabolism maps yielded extremely high discriminative power, distinguishing DLB from ADD and PD conditions with an accuracy of > 90%." Do we know exactly why glucose metabolism declines in these various regions in the brains of people with neurodegenerative disorders? Is it as simple as loss of (metabolically active) tissue?
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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease.

I have corresponded with James Clement about the possibility that elevated PARP-1 activity may a primary cause of the decline of NAD+ during aging, because PARP-1 consumes NAD+ as a cofactor in its activity. This group reports that PARP-1 also apparently accelerates the formation of toxic alpha-synuclein, and in at least one model, PARP-1 inhibition or deletion could prevent alpha-synuclein toxicity. PARP-1 inhibition or deletion does not seem like an enduring solution, as it leaves us tinkering with metabolism instead of cleaning up damage. I do wonder why PARP-1 is upregulated during aging; perhaps if we address the cause of this upregulation, we could prevent these negative downstream effects.
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Cell-penetrating artificial mitochondria-targeting peptide-conjugated metallothionein 1A alleviates mitochondrial damage in Parkinson’s disease models.

This group created a cell-penetrating, mitochondria-targeting peptide and tested it in a cell culture model of Parkinson's disease by conjugating it to human metallothionein 1A, a protein involved in metal detoxification and anti-oxidation. I thought this method might be interesting to some researchers, if the specific use in Parkinson's disease is not interesting.
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Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

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Free longevity biomarker report

Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

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Free diabetes report

An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

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