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An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program.

This group characterized mesenchymal stem cells (MSC) from the bone marrow of humans of different ages and found older MSC to have many concerning characteristics, including senescent-like (enlarged) morphology, reduced proliferation ability, increased SA-beta-galactosidase, increased lipofuscin, and increased DNA damage and DNA damage response. Exposure of young hematopoetic stem cells to factors secreted by aged MSC impaired some aspects of their function.
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Hyaluronan keeps mesenchymal stem cells quiescent and maintains the differentiation potential over time.

I retained this one because I understand that hyaluronan is an important part of the extracellular matrix (ECM), and its synthesis declines with aging (see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/ ). I wonder whether this decline in hyaluronan synthesis may affect MSC function during aging. The article I linked to asserts that hyaluronan is synthesized primarily by MSC, so perhaps MSC have some type of damage that causes them to synthesize less hyaluronan, thereby accelerating the decline in their function.
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