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T-cell senescence contributes to abnormal glucose homeostasis in humans and mice.

There have been some reports suggesting that aging is associated with impaired insulin sensitivity, and there are many studies reporting an age-associated increase in some inflammatory factors. This group reports that it may be senescent CD8+ T cells that contribute to both of these phenomena. Among other observations, they found that humans with diabetes or prediabetes had higher levels of senescent T cells, which in turn had higher expression levels of cytokines and cytotoxic molecules. Mouse models of aging and diet-induced obesity also had some of these characteristics.
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CMV immune evasion and manipulation of the immune system with aging.

These researchers outline some of what seems to be the most critical questions in CMV research as it relates to human aging. They mention in the abstract that this is a meeting report. I scanned the full-text and it looks like an interesting read, though it may not offer much new to people very familiar with the state-of-the-art in this field.
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Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4+ T Cells.

These researchers report that, in mice, thymus removal at a young age accelerates the development of "senescence-associated T cells", while thymus implantation at an old age slows the increase of senescence-associated T cells. If I understand the abstract correctly, it seems that the relative absence of healthy (youthful) thymic tissue is "highly permissive for spontaneous proliferation of transferred naive CD4+ T cells"--a potential cause of this T cell senescence. The thymic implantation at older age also restricted proliferation (and the associated senescence) in older mice.
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Do human B-lymphocytes avoid aging until 60 years?

Here, these researchers characterize gene expression profiles of naive and B cell populations in humans of various ages. They report no apparent differences between age groups 30-45, and 50-60; only after 60 years of age does there appear to be significant changes in B cell gene expression (and therefore, presumably, function).
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Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

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Free longevity biomarker report

Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

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Free diabetes report

An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

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