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Age estimation based on different molecular clocks in several tissues and a multivariate approach: an explorative study.

These two biomarkers--pentosidine and D-aspartic acid--were able to predict chronological age with a mean absolute error of 4.0 years in this study. This seems interesting (I had never heard until now that D-aspartate accumulates during the lifespan), but these seem like biomarkers that might be "gamed" or "fooled" relatively easily by interventions that would affect the biomarker, but not the level of system-wide biological damage in the organism. The same idea holds true for other "aging biomarkers" such as testosterone, IGF-1, and DHEA-S. I wonder what others think of this report.
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Bioenergetic basis for the increased fatigability with ageing.

These researchers compared changes in exercise metabolites in young and old humans and found some very high correlations between the age-related increase in power loss during exercise and several metabolites (including intracellular pH, phosphate, and diprotonated phosphate). This makes me wonder: what age-related, stable, accumulating damage could be causing this apparent failure to clear these muscle contraction metabolites in aged human muscle?
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Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

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Free longevity biomarker report

Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

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Free diabetes report

An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

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