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Age related changes in cell stiffness of tendon stem/progenitor cells and a rejuvenating effect of ROCK-inhibition.

These researchers report that tendon stem/progenitor cells apparently "stiffen" with age, as well as increase in size. I tagged this paper as being related to "cytoskeleton", assuming changes in the cytoskeleton may be the cause of this increased stiffness. They also report that treatment with a ROCK inhibitor reversed these age-related changes. I wonder what's going on here.
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Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo.

This group reports a remarkable association between plasma glucosepane and osteoarthritis, with as much as a 6-fold increase in advanced human osteoarthritis compared to controls. They also report some corroborating observations in guinea pig osteoarthritis. I wonder what glycation researchers make of *plasma* glucosepane being the compartment where glucosepane was assessed. If glucosepane is formed in collagen, how does it make it into plasma? Is it simply caused by normal tissue turnover? But if so, wouldn't that mean that collagen-glucosepane could theoretically be turned over into plasma and removed or excreted from there? Maybe a kind of blood filtration/scrubber could be used to remove it?
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Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension.

These results seem remarkable: daily treatments in mice with compound H, a possible activator of DNA demethylases, caused what appears to be improvements in multiple parameters in aging mice, including attenuation of the age-related rise in pulse-wave velocity and blood pressure, reduction in the stiffness of collagen, decreases in some MMPs, and increases in Sirt1, AMPK, Klotho, and eNOS.
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Accumulation of carboxymethyl-lysine (CML) in human cortical bone.

This group reports on an apparently new method of assessing CML in bone, and show that CML is present in bone at 40-100 times greater concentration than pentosidine. They suggest this might have relevance to bone fragility, and invite readers to use their method of extracting and measuring CML from human bone.
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Free report on high blood pressure

The American Heart Association estimates more than 100 million Americans have high blood pressure, also known as “hypertension”. Learn more about the cause of high blood pressure and how you can reverse it in our free report.

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Biomarker levels predict the risk of early death—and we can change them! Learn about some important longevity biomarkers in our free report.

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An estimated 50% of American adults have either prediabetes or type 2 diabetes. Learn more about the cause of type 2 diabetes, prediabetes, insulin resistance, and how to reverse them in our free report.

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