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Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes.

There have been some reports that nicotinamide can affect human mortality from skin cancer (e.g. see PMIDs 22297641 and 28468736), and I presume NAD+ replenishment is at least of some interest to Methuselah and SRF. Here, this group reports that nicotinamide significantly affects differentiation and proliferation of different types of skin cells in cell culture, and these effects can be influenced by impairing nicotinamide's conversion to NAD+, suggesting that NAD+ might be involved in this association between skin cancer and nicotinamide.
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Methioninase Gene Therapy.

I'm not sure I've seen this approach to cancer before; this group used a gene therapy for methioninase to restrict the availability of methionine to cancer cells, which are apparently known to require more methionine than non-cancer cells. This treatment showed some interesting effects. I leave this for others on this distribution list to consider further.
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5-Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy.

This group reported that a combination of resveratrol and 5-azacytydine appeared to reverse some aspects of senescence, including increasing proliferation rate and "decreased apoptosis and senescence". They suggest that this rejuvenation may have been caused by induced changes in mitochondrial dynamics ("promoting mitochondrial fusion over fission). While only in cell culture, this seems like an interesting result.
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Fisetin is a senotherapeutic that extends health and lifespan.

This looks like a remarkable report of fisetin as a senolytic that reduces senescence markers "in multiple tissues", and extends the lifespan of mice when given in late life, while "restoring tissue homeostasis". I presume most people on this distribution list have heard of this paper already.
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MicroRNA-570 is a novel regulator of cellular senescence and inflammaging.

These experiments were done in cell culture but look potentially interesting. This group reports that inhibiting microRNA 570-3p (miR-570-3p) "reverses cellular senescence by restoring sirtuin-1", as well as "suppresses markers of cellular senescence (p16, p21, p27)...restoring cellular growth by allowing progression through the cell cycle". Inhibiting this microRNA also apparently inhibited some SASP factors. Can we learn something useful from the effects of this miRNA?
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Effects of young extracellular matrix on the biological characteristics of aged tendon stem cells.

If I recall correctly, a report similar to this one was presented at a SENS conference years ago; perhaps the presenter is among the authors of this paper? Here, this group reports that young extracellular matrix improved the function of old tendon stem cells. This seems like a remarkable result. Does anyone know yet why ECM makes such a significant difference in stem cell function? I also tagged this as related to parabiosis, thinking that stem cells in old animals have access to young ECM in heterochronic parabiotic pairs. Perhaps this access to young ECM is among the factors positively affecting old animal function in these pairs.
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Free report on high blood pressure

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