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Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?


Maximus Peto’s Commentary

If I’m understanding the abstract correctly, this group reported that CMV-specific T cells appear to *not* interfere with immune responses to novel (I presume) pathogens.


Do cytomegalovirus-specific memory T cells interfere with new immune responses in lymphoid tissues?
Geroscience. 2019 Apr;41(2):155-163.
Mladen Jergović, Jennifer L Uhrlaub, Nico A Contreras, Janko Nikolich-Žugich
DOI: 10.1007/s11357-019-00068-0
PubMed publication date (edat): 5/10/2019

Abstract

In both mice and humans, the CD8 T cell compartment is expanded with age in the presence of a cytomegalovirus (CMV) infection due to an absolute increase in the CD8+ T cell effector memory (TEM) cells.
It has been hypothesized that in CMV+ subjects, such accumulated TEM cells could interfere with responses to new infection by competing for space/resources or could inhibit new responses by other, undefined, means. Here we present evidence against this hypothesis.
We show that MCMV-specific CD8 T cells accumulate in blood and bone marrow, but not lymph nodes (frequent sites of immune response initiation), in either persistent lifelong CMV infection or following reactivation. Moreover, adoptive transfer of effector memory T cells from MCMV positive mice into naïve animals did not interfere with either humoral or cellular response to West Nile virus or Listeria monocytogenes infection in recipient mice. We conclude that MCMV infection is unlikely to inhibit new immune responses in old animals through direct interference of MCMV-specific CD8 T cells with the priming.

PMID: 31069636
Free Full-Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6544713/

Maximus Peto

Max Peto is a longevity researcher and founder of Long Life Labs. A biochemist by training, he studies the biochemistry of aging and longevity and has worked with research organizations such as SENS Research Foundation, Methuselah Foundation, BioAge Labs, Life Extension Foundation, and Ichor Therapeutics. His work at Long Life Labs is focused on empowering people to understand and manage the most critical factors for better health and longer life.

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