Caffeine, Energy Expenditure, and Aging

In the context of a ketogenic diet, modest calorie restriction, and regular exercise, I have been considering re-introducing caffeine into my daily routine. I removed it months ago because there is substantial evidence that it induces a kind of transient insulin resistance (discussed in this article) – something I didn’t want when I was consuming substantial daily carbs. I also briefly discuss my hypothesis of energy production failure as a primary cause of aging degeneration, and support that with (very few) references (for now)…….

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Confirmed: Exercise Increases Day-After Ketones

Just a week ago, I received my blood ketone meter. I tested my fasted ketones, and found they were somewhat low. After eating what I thought was a low carb (ketogenesis-friendly) meal, I tested them again, and ketones had dropped, and glucose went to 105. Yikes. So I became more strict on carbs, and increased my exercise, and this is what happened…

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Glycogen and leptin: a neglected interaction in fat loss? Part 2 of 2

(You can find the first post in this two-part series here). Glycogen Glycogen is the storage form of carbohydrate in humans. From what evidence I could gather (which is not as much as I’d like), it appears that humans can store up to 600 g (454 g/lb = 1.32 lbs) of glycogen (see PMID 3165600). I suppose that this will vary depending … Read article…

Glycogen and leptin: a neglected interaction in fat loss? Part 1 of 2

Back in May of 2007, I began a serious – and successful – weight loss effort. I was ~220 lbs (5’8″), and was, well, fat. I read all about glucose, insulin, glycemic index, and other topics, and after implementing what I learned, I lost ~60 lbs in 6 months. I’m now at – 6 years later – about the same … Read article…

Human fatty acid metabolism: engineering a deficit for ketosis – Part 1

One of my longevity research acquaintances has spent considerable time investigating the scientific literature on very low carbohydrate (i.e. “ketogenic”) diets. I have not researched this topic as carefully as my acquaintance, and what I’m told makes me curious. Before I started scanning the science literature on this topic in past last week, some parts of what I’m told by this … Read article…